The disappearance of Flight 370 isn't just weighing on the families of these passengers.
It's also causing the surviving family members of other plane crashes to re-live their own tragedies.
CNN's Kyung Lah spoke to a woman whose father's plane vanished more than 60 years ago – but still can't find the closure she needs.
Darlene Larson was just 5 years old when her father, Leo, boarded Northwest Orient Flight 2501 at La Guardia Airport on June 23, 1950.
He was flying home to Minneapolis but never made it. The DC-4 plane with 58 passengers crashed into Lake Michigan, becoming at that time, the worst commercial aviation disaster in U.S. history.
The fuselage and engine never foundâ€” the only remnants discovered were a few body parts.
Larson says she was awoken by her mother crying, do her best to tell her that her father "would not be coming back."
"It's a hard concept because you don't have anything to hold onto," Larson said. "Like a funeral, a casket, or a grave. I was certain he was wandering around Chicago with amnesia and would realize where he was and would come home."
A U.S. official tells CNN Malaysia Airlines Flight 370 flew erratically and registered dramatic changes in altitude on the morning it vanished a week ago.
For the families of passengers of the missing plane - it's been an agonizing wait for answers.
They are still clinging to some hope that their loved ones have landed somewhere and are still alive.
CNN's David McKenzie is OutFront in Beijing and he spoke to a family member who hopes Flight 370 was a victim of a hijacking.
"This situation has broken my heart," Father of a Flight 370 passenger said. "My tears have run dry. I hope the plane was hijacked, because then at least there is hope."
A U.S. official tells CNN that radar showed erratic movements by a plane that the U.S. believes is flight 370 in the early morning hours when it disappeared.
The New York Times is also reporting that the missing airliner experienced significant changes in altitude after it lost contact with ground control.
Military radar signals appear to show the plane climbing to 45,000 feet just after it made a sharp turn to the west and disappeared.
That's above the approved altitude limit.
CNN's Martin Savidge is OutFront in a 777 simulator.
Last year at this time a new Pope had just been elected and no one could have predicted how popular Pope France would become.
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